Denigma

Sir2 mutation

Species: Fruit fly (Taxid: 7227)
Factor: Sir2
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

A decrease in Sir2 (alias dSir2) blocks the life-extending effect of caloric reduction or rpd3 mutations [15520384]. Sir2 mutation does not reduce lifespan under AL [15520384].


References:
  • 15520384: Sir2 mediates longevity in the fly through a pathway related to calorie restriction.
  • 17159295: Involvement of Drosophila Sir2-like genes in the regulation of life span.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Edit / Update (Admin) | Delete

    Comment on This Data Unit