Sir2 overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Sir2
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of Sir2 (alias dSir2) extends lifespan by up to 57% and specifically median lifespan by 40-60%. Ubiquitous Sir2 overexpression causes a 4-fold increase in Sir2 mRNA expression and an up to 57% increase in average lifespan (29% for females and 18% for males). A 10 - 20% increase in Sir2 mRNA levels causes no lifespan extension. Neuronal Sir2 overexpression extends average lifespan by 52% in females and 20% in males. Motor-neuronal specific expression fails to cause lifespan extension. DR fails to cause further increase in lifespan or even reduces lifespan toward normal of dSir2 overexpression mutants [15520384]. Mild Sir2 overexpression in the fat-body extends lifespan and reduces relative body fat content in both males and females [22661237].

A diet-dependent lifespan phenotype of dSir2 overexpression in the fat-body, but not in muscles, negates the effects of background genetic mutants [23246004].

Mean: +18 to + 57
Median: +4- to +60

References:

15520384: Sir2 mediates longevity in the fly through a pathway related to calorie restriction.

22661237: The second international conference "genetics of aging and longevity".

23246004: dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner.

Aging Relevance Analysis/Source:

GenAge

GenDR

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