Denigma

foxo mutation

Species: Fruit fly (Taxid: 7227)
Factor: foxo
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

foxo null mutants are highly and significantly shorter-lived than wild-type on all food dilutions apart from 0.1 SY and under starvation. foxo null mutants are not more sensitive to starvation than wild-type [18241326].


References:
  • 18241326: Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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