Denigma: Intervention

Thor overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Thor
Manipulation: Gain-of-Function, Overexpression
Effect:

Ubiquitously overexpression of wild-type Thor (alias d4E-BP) causes no change under AL, but an activated allele (with more than 3-fold increased binding activity to delF4E) significantly extends lifespan of females (weak allele) and females as well as males (strong allele). Mean lifespan is extended by 11 to 40%. Median lifespan of males and females is enhanced by by 11 and 22%, respectively. Maximum lifespan is extended by 16 and 18% for males and females, respectively. Under DR (0.25% YE) there is no lifespan extension, beyond the effect of DR alone, in all (wild-type, weak and strong) Thor alleles [19804760].

Lifespan of animals with increased Pten and 4E-BP activity in muscle exhibit and extended mean and maximum lifespan by 20% and 15.8% [21111239].

Mean: +11 to +40
Median: +11 to +22
Maximum: +16 to +18

References:

19804760: 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

21111239: FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging.

Aging Relevance Analysis/Source:

GenAge