CG5389 RNAi

Species: Fruit fly (Taxid: 7227)
Factor: CG5389
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNAi of complex V subunit CG5389 results in increased mean longevity under standard laboratory food conditions (3% yeast) in males. RNAi started from the development results in a mild lifespan increase in both sexes (3-11% in females and 3-8% in males). Post-developmental RNAi and silencing limited to neurons has variable effects with reduction in lifespan of up to 9% [19747824]. Under rich media conditions CG5389 knockdown throughout development and adulthood increases mean lifespan by 26% and abolished the lifespan extension by DR (started in the adulthood) in males. Suppression of CG5389 only during the adulthood either via RNAi by tub-GS or via oligomycin (a specific inhibitor of complex V) feeding prevents an increase in longevity under DR (started in the adulthood) in males [19968629].

Mean: -9 to +26

References:

19968629: Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila.

19747824: Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain.

Aging Relevance Analysis/Source:

GenAge

GenDR

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