Propargylglycine treatment

Species: Fruit fly (Taxid: 7227)
Factor: Eip55E
Manipulation: Diet Intervention, Drug treatment
Effect:

Propargylglycine (PPG) inhibits gamma-cystathioinase, the second enzyme of the trans-sulfuration pathway (TSP). PPG is a specific suicidal inhibitor of gamma-cystathionase. Gluthatione (GSH) levels are decreased by PPG administration in flies subjected to DR, whereas there is no effect on fully fed animals. PPG robustly suppresses DR lifespan extension, while longevity of fully fed flies is not affected in different strains. Thus, indicating that the effect of PPG is specific to DR. PPG abrogates changes in lifespan that are normally observed when flies are maintained in different dietary concentrations and compositions [21930912].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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