Curcumin treatment

Species: Fruit fly (Taxid: 7227)
Factor:
Manipulation: Diet Intervention, Drug treatment
Effect:

In fruit fly, 0.5 an 1.0 mg/g curcumin in the diet increases mean lifespan by 6.2 and 25% in females and by 15.5 and 12.6 in males, respectively. Lifespan extension by curcumin was associated with the increased superoxide dismutase (SOD) activity, upregulation of Ms-SOD and CuZn-SOD genes, and the downregulation of dInR, ATTD, Def, CecB and, DptB genes as well as reduction of lipofuscin, malondialdehyde and lipid peroxidation [22653297; 23325575]. Curcumin prolongs life and enhances activity of fruit fly Alzheimer diseased flies [22348084].

Mean: +6.2 to +25

References:
  • 22653297: Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila.
  • 22348084: Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.
  • 23325575: Curcumin and aging.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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