Denigma

shc-1 knockout

Species: Nematode (Taxid: 6239)
Factor: shc-1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Loss of shc-1 function results in accelerated aging and enhanced senstivity ro heat, oxidative stress and heavy metals.


References:
  • 18832074: SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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