Prkar2b knockout

Species: House mouse (Taxid: 10090)
Factor: Prkar2b
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Loss of function of Prkar2b results in mice that are lean and insulin sensitive. Both median and maximum lifespan is increased by 14%. Median lifespan is increasesd (from 884 to 1005) and 80% lifespan increased from 941 to 1073 days. There is no difference either in median or 80% lifespan in female genotypes [19536287].

Median: +0 to +14
Maximum: +0 to +14

References:
  • 19536287: Disruption of protein kinase A in mice enhances healthy aging.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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