eat-2 mutation

Species: Nematode (Taxid: 6239)
Factor: eat-2
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

eat-2 mutations result in partial starvation by disrupting the function of the pharynx and an approximately 50% extension of lifespan. eat-2 mutants life significant longer by up to 57% [9789046]. eat-2(ad1116) mutants have an extended mean, 75%ile and maximum lifespan by 30, 35, and 24% [22810224]. sDR further increases the long lifespan of eat-2 mutants [19239417]. eat-2 mutants live longer than wild-type at high food concentration but are short lived at lower concentrations (via bacterial dilution) [19229346]. eat-2(ad1113) mutation increases mean lifespan by 56% and is non-additive with SCNA overexpression [16782295]. Combining eat-2 mutation with bacterial deprivation DR does not result in an additive increase in lifespan [17081160;17096674]. Loss of function of eat-2 extends lifespan by 20-30%. Lifespan extension is proposed to be similar to DR. eat-2;daf-2 double mutant live longer than daf-2 single mutants [9789046]. Therefore, eat-2 mutants can synergize with daf-2 mutants, but not with clk-1 mutants, for lifespan extension. Lifespan extension conferred by eat-2 is not suppressed by daf-16 mutation [9789046].

Mean: +30 to +57
Maximum: +24

References:
  • 16782295: Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein.
  • 18331616: Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.
  • 19239417: Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans.
  • 19229346: Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans.
  • 17081160: Lifespan extension in Caenorhabditis elegans by complete removal of food.
  • 17096674: Dietary deprivation extends lifespan in Caenorhabditis elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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