Tert re-activation

Species: House mouse (Taxid: 10090)
Factor: Tert
Manipulation: Gain-of-Function
Effect:

Re-activation of telomerase in a model of premature aging caused by accelerated telomere shortening (duo to telomerase deficiency) was enough to revert some age-associated phenotypes [21113150].

Mice lacking telomerase age more rapedely and died earlier, as an abundance of critically short telomeres developed. Reawakening of Tert, leads to disappearment of age-related symptoms and rejuvenation occurred in several organs including their brains [http://www.isagenixhealth.net/blog/2012/05/16/telomerase-stimulation-extends-lifespan-in-mice/].


References:
  • 21113150: Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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