Denigma

Tert overexpression

Species: House mouse (Taxid: 10090)
Factor: Tert
Manipulation: Gain-of-Function, Overexpression
Effect:

Mice genetically modified to express telomerase lived 40% longer and do not develop cancer. Overexpression of Tert in mice engineered to be cancer-resistant by means of ehanced expression of p53, p16 and p19ARF (Sp53/Sp16/SARF/TgTERT) decreased telomere shortening with age, delayed aging and increases mean and median longevity by 40% [19013273].

Mean: +40
Median: +40

References:
  • 19013273: Telomerase reverse transcriptase delays aging in cancer-resistant mice.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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