Denigma

smk-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: smk-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNA interference of smk-1 completely suppresses the extended longevity of daf-2 mutations and partly the life-extension of clk-1 mutants. smk-1 RNAi decreases mean and maximum lifespan of similar level than daf-16 knockdown [16530049]. smk-1 RNAi only slightly shortens the lifespan of wild-type worms, but abolishes the extended lifespan of eat-2 mutants [17476212].


References:
  • 16530049: SMK-1, an essential regulator of DAF-16-mediated longevity.
  • 17476212: PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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