rict-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: rict-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

C. elegans with mutations in the TORC2 complex gene rict-1 (Rictor) grow slowly and have small body size, and live slightly longer than wild-type when maintained on “rich” food such as the RNAi feeding strain HT115 and at elevuated temperature (25 degree Celsius) [Soukas et al., 2009 in (Robida-Stubbs et al., 2012)]. rict-1 RNAi at 20 degree Celsius in the adulthood increases mean, median, 75th %ile and maximum lifespan by 12-42, 22-29, 13-32 and 28-54%, respectively, dependent on skn-1. daf-16 is not required for lifespan to be increased by rict-1 RNAi, or when TORC1 and TORC2 are blocked by ragc-1;rict-1 RNAi. rict-1 RNAi extends mean, median, 75th %ile and maximum lifespan in the intestine-specific RNA stains VPS288 by 12-18, 19, 13-18 and 16%, respectively [22560223].

Mean: +12 to +42
Median: +22 to +42
Maximum: +28 to +54

References:

22560223: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Aging Relevance Analysis/Source:

GenAge

GenDR

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