Denigma: Intervention

ifg-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: ifg-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNA interference against ifg-1 in the adulthood results in a 55% mean lifespan extension [17411345]. ifg-1 RNAi only in the adulthood increases mean, median and 75th %ile lifespan by 49, 33, and 35%, respectively [22560223]. RNAi knockdown of ifg-1 continuously at 25.5 degree Celsius extends mean and maximum lifespan by 31 and 11%, while knockdown restricted to the adulthood extends mean and maximum lifespan by 45 and 28% [16720740].

Mean: +31 to +55
Median: +33
Maximum: +11 to +28

References:

17411345: Lifespan regulation by evolutionarily conserved genes essential for viability.

22560223: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

16720740: daf-16 protects the nematode Caenorhabditis elegans during food deprivation.

Aging Relevance Analysis/Source:

GenAge