Denigma

eif-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: eif-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNA interference against eif-1 in the adulthood extends mean lifespan by 25% [17411345]. eif-1 RNAi only during the adulthood increases mean, median and 75th %ile lifespan by 23-35, 38 and 22-40%, respectively [22560223].

Mean: +23 to +35
Median: +38

References:
  • 22560223: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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