Denigma: Intervention

rheb-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: rheb-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

rheb-1 RNAi extends lifespan by mimicking the DR effect. Under AL condition, rheb-1 RNAi extends lifespan by 19.1% and the longevity-promoting effects of two DR regimens sDR and intermittent fasting are abolished [19079239]. Knockdown of rheb-1 by RNAi only during the adulthood increases mean, median and 75th %ile lifespan by 18-25, 25 and 23-24%, respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Knockdown of rheb-1 dramatically enhances stress tolerance in an skn-1, but not daf-16-dependent manner [22560223].

Mean: +18 to +25
Median: +25

References:

22560223: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

19079239: Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.

Aging Relevance Analysis/Source:

GenAge