hcf-1 mutation

Species: Nematode (Taxid: 6239)
Factor: hcf-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

hcf-1 inactivation by mutation cause a daf-16-dependent lifespan extension of up to 40% and heightened resistance to specific stimuli [18828672].

HCF-1 forms a complex with DAF-16. hcf-1 inactivation by mutation cause a daf-16-dependent lifespan extension of up to 40% and heightened resistance to specific stimuli. The hcf-1(ok559) mutation increases mean and maximum lifespan by 10-37 and 29%, while the strong hcf-1(pk924) mutation extends mean and maximum lifespan by 29-31 and 53-88%, respectively. In the absence of hcf-1 there is a greater enrichment of DAF-16 at its target gene promoters and more robust DAF-16-mediated regulation of selective transcriptional targets. hcf-1 mutation extends lifespan of glp-1(e2141) mutants which lack germline cells, [18828672].

Mean: +10 to +37
Maximum: +29 to +88

References:
  • 18828672: Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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