Denigma

ectopic Trp53 overexpression

Species: House mouse (Taxid: 10090)
Factor: Trp53
Manipulation: Gain-of-Function
Effect:

Mutant mice with activated Trp53 display enhanced resistance to spontaneous tumours and signs of premature ageing including reduced lifespan, osteoporosis, organ atrophy and a diminished stress tolerance [11780111].


References:
  • 11780111: p53 mutant mice that display early ageing-associated phenotypes.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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