Denigma: Intervention

daf-4 mutation

Species: Nematode (Taxid: 6239)
Factor: daf-4
Manipulation: Loss-of-Function, Mutation
Effect:

daf-4(e1374) mutation increases mean and maximum lifespan by 40-120% and 76-83%. daf-4(m63) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 [11242085]. mutation of daf-4 results in a temperature-sensitive, dauer-constitutive phenotype in larvae. sir-2.1 overexpression in the daf-4(m63) background results in an increase in the severity of the dauer-constitutive phenotype [11242085].

Mean: +40 to +120
Maximum: +76 to +83

References:

17900898: The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.

11242085: Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.

Aging Relevance Analysis/Source:

GenAge