Denigma

atg-7 RNAi

Species: Nematode (Taxid: 6239)
Factor: atg-7
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNA interference against atg-7 shortens mean lifespan by 23% and maximum lifespan by 30% in a eat-2 mutant background but not in wild-type animals. Thus, atg7 RNAi does not affect lifespan of wild-type, but totally cancels out the lifespan extension effect of eat-2 mutation [17912023].


References:
  • 17912023: Autophagy is required for dietary restriction-mediated life span extension in C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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