mdh-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: mdh-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNAi against mdh-1 decreases median lifespan by 10% in wild type animals and by 16% in daf-2 mutants. mdh-1 RNAi started after the animal reached the late L4 stage increases mean and maximum lifespan by 4-27% and 9% [22103665].

Mean: +4 to +27
Median: -10
Maximum: +9

References:
  • 22103665: Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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