Denigma

RAS2 deletion

Species: Budding yeast (Taxid: 4932)
Factor: RAS2
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

RAS2 deletion causes a 23% decrease in mean and a 30% decrease in maximum lifespan [8034612]. Deletion of RAS2 leads to a longer chronological lifespan [21076178]. Deletion of the RAS2 gene, which functions upstream of CYR1, doubles the mean chronological lifespan by a mechanism that requires Msn2/4 and Sod2 [12586694]. DR further extends chronological lifespan of ras2Delta [18225956].

Mean: -23
Maximum: -30

References:
  • 21076178: Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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