Denigma

pas-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: pas-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNAi against pas-1 started after the animal reached the late L4 stage decreases mean lifespan by 18-19% [22103665]. RNAi pas-1 decreases lifespan of daf-2 mutant, but not of WT or glp-1 mutant [17392428].

Mean: -18 to -19

References:
  • 22103665: Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan.
  • 17392428: Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Edit / Update (Admin) | Delete

    Comment on This Data Unit