Denigma

phi-44 RNAi

Species: Nematode (Taxid: 6239)
Factor: phi-44
Manipulation: Gain-of-Function, Loss-of-Function, Knockout
Effect:

phi-44 RNAi leads to 46% mean and 50% maximum lifespan extension. Lifespan extension by phi-44 is not suppressed by daf-16.

phi-44 RNAi animals have lower ATP content and oxygene consumption [12447374].

Mean: +46
Maximum: +50

References:
  • 12447374: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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