Denigma

HXK2 deletion

Species: Budding yeast (Taxid: 4932)
Factor: HXK2
Manipulation: Loss-of-Function, Knockout, Deletion
Effect:

Deletion of HXK2 extends mean and maximum replicative lifespan by about 53% and 33%, respectively. Limiting glucose availability by mutating HXK2 significantly extends replicative lifespan and provides a genetically model of DR [11000115]. HXK2 deletion increases oxygene consumption. Changes in gene expression HXK2 mutation are quite similar to those of dietary-restricted cells. In fact, HXK2 mutants have a transcriptional profile that significantly resembles DR cells and cell overexpressing HAP4 [12124627].

Mean: +53
Maximum: +33

References:
  • 11000115: Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
  • 12124627: Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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