Denigma: Intervention

age-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: age-1
Manipulation: Gain-of-Function, Loss-of-Function, Knockout
Effect:

RNAi against age-1 extends lifespan by 30% [8700226; 8608934]. age-1 RNAi increases mean and maximum lifespan by 36-46% and 48-50% [12447374]. RNAi against age-1 increases mean lifespan by 83% [18828672]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672].

Mean: +36 to +99
Maximum: +48 to +117

References:

22484922: Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.

18828672: Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.

Aging Relevance Analysis/Source:

GenAge