Reduced expression of Loco due to hetero-deficient results in a 17-20% longer mean lifespan for both male and females, besides the fact that the homozygous deficiency of loco is lethal. Several of these long-lived mutants are more resistant to stresses such as starvation, oxidation ad heat. Additional mutant have higher Manganese-containing superoxide dismutase (MnSOD) activity, increased fat content an diminished cAMP levels. Loco RGS domain is required for the regulation of longevity as deletion analysis suggest [21776417].
Mean: +17 to +20
GenAge
GenDR
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