Lnk mutation

Species: Fruit fly (Taxid: 7227)
Factor: Lnk
Manipulation: Loss-of-Function, Mutation
Effect:

Loss of Lnk function results in increased median (14% in females and 17.5 in males) and maximum lifespan, reduced female fecundity and improves survival under conditions of oxidative stress and starvation. Heterozygousity does not result in any significant differences in lifespan in either males or females. Moreover, lifespan extension in one of the female homozygous mutant is fully rescued by the introduction of a Lnk genomic rescue construct [20333234].

Median: -14 to -17.5

References:
  • 20333234: Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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