Denigma

esc mutation

Species: Fruit fly (Taxid: 7227)
Factor: esc
Manipulation: Loss-of-Function, Mutation
Effect:

Males heterozygous for the null esc4 or the dominant negative esc9 mutation that are progeny of an out-cross to a O-R wild-type strain have median lifespan that is, respectively, 47% and 60% longer than the O-R control. When derived from an out-cross to a longer-lived C-S wild-type strain, heterozygous esc9 flies have a median lifespan that is 43% longer than the C-S control [20018689].

Mean: +47 to +60
Maximum: +34

References:
  • 20018689: Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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