dys knockout

Species: Fruit fly (Taxid: 7227)
Factor: Dys
Manipulation: Loss-of-Function, Knockout
Effect:

Loss of dys function in the heart leads to an age-dependent disruption of the myofibrillar organization within the myocardium as well as to alterations in cardiac performance. Mesodermal dys knockout results in a morderate maximum lifespan reduction (13%), but not when exclusively targeted to the heart. In contrast, half of the transheteozygous DysExel618/Dyskx43 deficiency flies die at 29 days compared to 63 days in controls. This indicates that a moderate dye loss-of-function in all muscles, but not in just the heart, reduces the normal lifespan [18221418].

Maximum: -13

References:
  • 18221418: Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



  • Edit / Update (Admin) | Delete

    Comment on This Data Unit