Denigma

GCN4 Deletion

Species: Budding yeast (Taxid: 4932)
Factor: GCN4
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of GCN4 increases the replicative lifespan by 10% in the alpha strain [19030232]. GCN4 deletion decreases the lifespan in the alpha and a strain [20657825].

The chronological lifespan of GCN4 deletion is strongly decreased in the a strain [20421943].

Mean: +10

References:
  • 20657825: Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.
  • 19030232: Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
  • 20421943: A microarray-based genetic screen for yeast chronological aging factors.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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