Jafrac1 overexpression

Species: Fruit fly
Factor: Jafrac1
Manipulation: Gain-of-Function, Overexpression
Effect:

Neuronal overexpression of Jafrac1 significantly increases both mean and maximum lifespan, while neuronal knockdown as well as loss of function mutation, causes a reduction in lifespan by 30%. The mean lifespan is 26% and 29% higher in females and males, respectively. The maximum lifespan is increased by 22% and 26% in females and males, respectively [19720829].

There is a consistent and significant lifespan extension (15% mean lifespan increase) in both males and females when Jafrac1 is overexpressed in somatic cells. Jafrac1 overexpression using the weaker 5961FS driver moderately but significantly extends lifespan [20976250].

Mean: +15 to +29
Median: +22 to +26

References:
  • 19720829: JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.
  • 20976250: Lifespan extension by preserving proliferative homeostasis in Drosophila.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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