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Lifespan
>
Interventions
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ERCC1 and ERCC4 deficieny
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Mouse Lifespan Experiments
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ERCC1 and ERCC4 deficieny
Factor
:
Ercc4
Manipulation:
Loss-of-Function
,
Mutation
Effect:
ERCC1-ERCC4-deficient mice exhibit signs of premature aging [
17183314
].
References:
17183314: A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
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