Denigma: Intervention

Cdkn1a knockout

Species: House mouse (Taxid: 10090)
Factor: Cdkn1a
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of Cdkna1 (alias p21) prolongs the lifespan of telomerase-deficient mice with dysfunctional telomeres and improves the repopulation capacity and self-renewal of hematopoietic stem cells [17143283].

The p21(-/-) strains like the Cdkn1a(tmi/Tyj) exhibits enormous regenerative capacities as it closes ear holes similar to MRL mice [20231440; 21722344].

References:

17143283: Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.

20231440: Lack of p21 expression links cell cycle control and appendage regeneration in mice.

21722344: The role of p21 in regulating mammalian regeneration.

Aging Relevance Analysis/Source:

GenAge