Bax knockout

Species: House mouse (Taxid: 10090)
Factor: bax
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Inactivation of proapoptotic Bax extends fertile potential and minimized age-related health problems, including bone and muscle loss, excess fat deposition, alopecia, cataracts, deafness, increased anxiety, and selective attention deficit. Bax deficiency does not lead to an increase in tumor incidence. Despite the apparently increased quality of life of aging females lacing Bax, there is no significant differences in overall lifespan [17360389].


References:
  • 17360389: Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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