Wrn mutation

Species: House mouse (Taxid: 10090)
Factor: Wrn
Manipulation: Loss-of-Function, Mutation, Deletion
Effect:

Mice lacking the helicase domain fo the WRN ortholog exhibit many phenotypic features of Werner Syndrom, including a pro-oxidant status and a shorter mean lifespan. Mice with a deletion in the helicase domain [9789047] recapitulates most of the Werner syndrome phenotypes, including an abnormal hyaluronic acid excretion, higher reactive oxygen species levels, dyslipidemia, increased genomic instability, and cancer incidence. Wrn(Dehl/Dehl) mutant mice have a 10 - 15% decrease in their mean lifespan [12707040; 19741171].

Mean: -10 to -15

References:
  • 12707040: Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
  • 19741171: Vitamin C restores healthy aging in a mouse model for Werner syndrome.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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