C60-olive oil treatment

Species: Norway rat (Taxid: 10116)
Factor: Oo C60
Manipulation: Diet Intervention, Drug treatment
Effect:

Oral administration of C60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) for just about 7 months to rats not only does not entail chronic toxicity but it almost doubles the lifespan. The effects on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress. Dissolved C60 is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours [22498298].

C60-olive oil can increase the mean, median and maximum lifespan by 114, 91 and 74%. C60-olive oil extends the lifespan of animals with a probability of 0.999 and 0.995 with respect to water and olive oil treatments, respectively [22498298].

The GSSG/GSH ratio of animals treated by C60-oil is significantly less (about twice as less) as compared to controls [22498298].

Mean: +113.8
Median: +90.9
Maximum: +73.7

References:
  • 22498298: The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • None MUT vs. None ( male ) : 113.8(mean) 90.9(median) 73.7(max)



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