mir-14 mutation

Species: Nematode (Taxid: 6239)
Factor: mir-14
Manipulation: Loss-of-Function, Mutation
Effect:

Mutating mir-14 decreases lifespan in both sexes. mir-14 reduces the mean and maximum lifespan of females by 55 and 36%, respectively, while those of males is reduced by 29 and 21%, respectively [12725740].

Mean: -29 to -55
Maximum: -21 to -29

References:
  • 12725740: The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • mir-14 vs. wild-type ( 20°C female ) : -55.2(mean) -35.7(max)
  • mir-14 vs. wild-type ( 20°C male ) : -29.0(mean) -21.4(max)



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