gig overexpression

Species: Fruit fly (Taxid: 7227)
Factor: gig
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of gig, also known as dTsc2, results in lifespan extension. Overexpression of dTsc2 increases mean lifespan by 20% and 12%, at 25°C and 29°C, respectively, and protects from deleterious effects of rich food, as if mimicking the effect of DR [15186745].

Overexpression of dTsc2 via a UAS promoter in the eye using the driver gmr-GAL4 or in the nervous system by using appI-GAL4 does not extend the lifespan. Using the drivers 24BGAL4 and PO188-GAL4, enhancer traps that are predominantly expressed in the muscle and fat results in mean lifespan extension of 27% and 37%, respectively, at 29°C [15186745]. Fat-specific drivers DJ634-GAL4 and PO163-GAL4 when used to overexpress dTsc2, also led to a mean lifespan extension of 22% and 31%, respectively, at 29°C [15186745].

Mean: +20 to +31

References:

15186745: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.

Aging Relevance Analysis/Source:

GenAge

GenDR

Comparisons:

da-GAL4/UAS-dTsc2 vs. +/da-GAL4 : 11.5(mean) 19.4(max) <0.0001(p-value)

da-GAL4/UAS-dTsc2 vs. +/da-GAL4 : 19.0(mean) 12.8(max) <0.0001(p-value)

gmr-GAL4/UAS-dTsc2 vs. +/gmr-GAL4 : -12.9(mean) -9.5(max) <0.01(p-value)

appl-GAL4/UAS-dTsc2 vs. +/appl-GAL4 : 3.1(mean) <0.001(p-value)

24B-GAL4/UAS-dTsc2 vs. +/24B-GAL4 : 19.4(mean) 32.4(max) <0.0001(p-value)

DJ634-GAL4/UAS-dTsc2 vs. +/DJ634-GAL4 : 24.4(mean) 29.0(max) <0.0001(p-value)

PO163-GAL4/UAS-dTsc2 vs. +/PO163-GAL4 : 28.6(mean) 32.4(max) <0.0001(p-value)

da-GAL4/UAS-dTsc2 vs. +/da-GAL4 ( 29°C ) : -9.1(mean) <0.3(p-value)

da-GAL4/UAS-dTsc2 vs. +/da-GAL4 ( 29°C ) : 6.5(mean) <0.03(p-value)

da-GAL4/UAS-dTsc2 vs. +/da-GAL4 ( 29°C ) : 13.3(mean) <0.0001(p-value)

da-GAL4/UAS-dTsc2 vs. +/da-GAL4 ( 29°C ) : 21.4(mean) <0.0001(p-value)

da-GAL4/UAS-dTsc2 vs. +/da-GAL4 ( 29°C ) : 100(mean) <0.0001(p-value)

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