Denigma

VMA2 deletion

Species: Budding yeast (Taxid: 4932)
Factor: VMA2
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

VMA2 deletion mutants have a reduced ΔΨ and mitochondrial morphology similar to aged cells. The restoration of the vacuolar acidity in daughter cells requires V-ATPase activity as it is eliminated in VMA2 deletion mutant cells [23172144]. VMA2 deletion mutation decreases the mean replicative lifespan by 80% in the alpha strain [18340043]. Deletion of VMA2 decreases mean, median and maximum replicative lifespan by 84%, 84% and 70%, respectively. DR (0.5% glucose restriction) does not extend the replicative lifespan of VMA2 and shortens it even more [23172144].

Mean: -80 to -83.9
Median: -84.1
Maximum: -70.0

References:
  • 18340043: Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.
  • 23172144: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
    • Comparisons:
  • vma2 vs. WT : -83.9(mean) -84.1(median) -70(max) <0.0001(p-value)
  • vma2 DR vs. WT : -93.5(mean) -93.7(median) -76(max) 0.0398(p-value)

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