jnk-1 overexpression

Species: Nematode (Taxid: 6239)
Factor: jnk-1
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of jnk-1 increases lifespan by 40% [15767565; 23097426].

JNK-1 overexpression extends the lifespan in a daf-16-dependent manner. JNK-1 overexpression does not extend the lifespan of animals unable to synthesize miRNAs, i.e. pash-1(mj100) [23097426].

Mean: +40

References:
  • 15767565: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
  • 23097426: Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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