Denigma: Intervention

lin-14 loss-of-function mutation

Species: Nematode (Taxid: 6239)
Factor: lin-14
Manipulation: Loss-of-Function, Mutation
Effect:

A loss-of-function mutation in lin-14 extends lifespan by 31% [16373574]. lin-14(n719) mutation extends mean and maximum lifespan of control animals by 20 and 67%, respectively [23097426].

The life-extending effects is dependent on daf-16 and hsf-1 [16373574]. Inactivation of lin-14 does not increase the lifespan of pash-1 mutants [23097426].

Mean: +20 to +31
Maximum: +67

References:

16373574: A developmental timing microRNA and its target regulate life span in C. elegans.

23097426: Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans.

Aging Relevance Analysis/Source:

GenAge