NF1 overexpression

Species: Fruit fly (Taxid: 7227)
Factor: NF1
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of NF1 increases mitochondrial respiration and reduced ROS production. It increases mean lifespan by 49% in males and 68% in females and maximum lifespan by 38% in males and 52% in females. It also improved reproductive fitness [17369827].

Mean: +49 to +68
Maximum: +38 to +52

References:
  • 17369827: Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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