Resveratrol supplementation

Species: House mouse (Taxid: 10090)
Factor: Res
Manipulation: Diet Intervention, Drug treatment
Effect:

Resveratrol conteracts the detrimental effects of a high-fat diet in mice an decreases the risk of death by 30% and thereby reverting it to the level of normal diet. It also partially corrected a subset of the abnormal gene expression profile and insulin as well as glucose metabolism [17086191].

Although resveratrol has a range of beneficial effects in elderly mice, it does not increase the longevity of ad libitum fed mice when started midlife [18599363]. Even at high doses and when started in young adulthood reseveratrol supplementation does not increase lifespan on a normal diet [17578509; 20974732].


References:
  • 17086191: Resveratrol improves health and survival of mice on a high-calorie diet.
  • 18599363: Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
  • 17578509: An Aging Interventions Testing Program: study design and interim report.
  • 20974732: Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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