Denigma

Hsp22 transposition

Species: Fruit fly (Taxid: 7227)
Factor: Hsp22
Manipulation: Loss-of-Function, Knockout, Mutation, Transposition
Effect:

Animals that do not express Hsp22 (due to a transposition into its transcriptional starting site) have a 40% decrease in lifespan, exhibit a 30% decrease in locomotor activity and are sensitive to mild stress [20036725].

Mean: -40

References:
  • 20036725: Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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