Denigma: Intervention

Hsp22 overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Hsp22
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of mitochondrial Hsp22 in all cells or specifically in motorneurons (using GAL4/UAS binary system) increases life lifespan by 32% and resistance to oxidative stress [19948727; 20036725].

Ubiquitous or a targeted expression of Hsp22 within motorneurons increases the mean lifespan by more than 30%. Hsp22 shows beneficial effects on early-aging events since the premortality phase displays the same increase as the mean lifespan [14734639].

Mean: +30 to 32

References:

20036725: Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22.

14734639: Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress.

19948727: Proproliferative functions of Drosophila small mitochondrial heat shock protein 22 in human cells.

Aging Relevance Analysis/Source:

GenAge