Denigma

cdc-25.1 RNAi

Species: Nematode (Taxid: 6239)
Factor: cdc-25.1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNA interference of cdc-25.1 results in increased thermotolerance and extended lifespan [16741121]. cdc-25.1 RNAi extends mean and maximum lifespan by 10 and 13%, respectively [21129974].

Lifespan extension by cdc-25.1 RNAi is cancelled out by mir-71 mutation [21129974].

Mean: +10.0
Maximum: +12.5

References:
  • 16741121: Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.
  • 21129974: MicroRNAs both promote and antagonize longevity in C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
    • Comparisons:
  • wild-type RNAi vs. wild-type ( 20°C ) : 10(mean) 12.5(max)

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