Sirt6 knockout

Species: House mouse (Taxid: 10090)
Factor: Sirt6 Sirt6
Manipulation: Loss-of-Function, Knockout
Effect:

Sirt6 knockout mice develop signs of premature ageing including a short lifespan [16439206].

Mice without Sirt6 have a higher risk of gastrointestinal cancers. Loss of Sirt6 increases the number, size and aggressiveness of tumors. Sirt6 loss leads to tumor formation even without activation of oncogenes. Transformed SIRT6-deficient cells exhibit increased glycolysis and tumor growth [23217706].


References:
  • 23217706: The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism.
  • 16439206: Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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