ins-35 mutation

Species: Nematode (Taxid: 6239)
Factor: ins-35
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Mutation of ins-35 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. ins-35(TM290) mutation extends mean, 75%ile, and maximum lifespan by 15-17, 14-23, and 23-24%. Lifespan extension by ins-35 mutation is totally abolished by daf-16 or skn-1 RNAi inactivation eat-2 RNAi further enhances the extension of lifespan by mutation in ins-35 [22768380].

Mutation of ins-35 enhances pheromone-induced dauer formation [22768380].

Mean: +15 to +17
Maximum: +23 to +24

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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